Chapter 31 Rhodococcus equi

  1. Magnusson H: Spezifische Infektioese Pneumonie beim Fohlen. Ein neuer Eitererreger beim Pferde. Arch Wiss Praktise Tierheildk 50:22, 1923.
  2. Finnerty WR: The biology and genetics of the genus Rhodococcus. Annu Rev Microbiol 46:193, 1992. PUBMED Abstract
  3. Quinn PJ, Markey BK, Carter ME, et al: Veterinary microbiology and microbial disease, Ames, Iowa, 2002, Blackwell.
    3a. Jones AL, Sutcliffe IC, Goodfellow M: Prescottia equi gen.nov., comb. Nov.: a new home for an old pathogen. Ant van Leeuwenhoek 103:655, 2013. PUBMED Abstract
  4. Fuhrmann C, Soedarmanto I, Lammler C: Studies on the rod-coccus life cycle of Rhodococcus equi. Zentralbl Veterinarmed B 44:287, 1997. PUBMED Abstract
  5. Hughes KL, Sulaiman I: The ecology of Rhodococcus equi and physiochemical influences on growth. Vet Microbiol 14:241, 1987. PUBMED Abstract
  6. Meijer WG, Prescott JF: Rhodococcus equi. Vet Res 35:383, 2004. PUBMED Abstract
  7. Riess FG, Elflein M, Benk M, et al: The cell wall of the pathogenic bacterium Rhodococcus equi contains two channel-forming proteins with different properties. J Bacteriol 185:2952, 2003. PUBMED Abstract
  8. Mosser DM, Hondalus MK: Rhodococcus equi: an emerging opportunistic pathogen. Trends Microbiol 4:29, 1996. PUBMED Abstract
  9. Chirino-Trejo JM, Prescott JF: Polyacrylamide gel electrophoresis of whole-cell preparations of Rhodococcus equi. Can J Vet Res 51:297, 1987. PUBMED Abstract
  10. Prescott JF: Capsular serotypes of Corynebacterium equi. Can J Comp Med 45:130, 1981. PUBMED Abstract
  11. Nakazawa M, Kubo M, Sugimoto C, et al: Serogrouping of R. equi. Microbiol Immunol 27:837, 1983. PUBMED Abstract
  12. Takai S, Sekizaki T, Ozawa T, et al: Association between a large plasmid and 15- to 17-kilodalton antigens in virulent Rhodococcus equi. Infect Immun 59:4056, 1991. PUBMED Abstract
  13. Takai S, Koike K, Ohbushi S, et al: Identification of 15- to 17-kilodalton antigens associated with virulent Rhodococcus equi. J Clin Microbiol 29:439, 1991. PUBMED Abstract
  14. Giguere S, Hondalus MK, Yager JA, et al: Role of the 85-kilobase plasmid and plasmid-encoded virulence-associated protein A in intracellular survival and virulence of Rhodococcus equi. Infect Immun 67:3548, 1999. PUBMED Abstract
  15. Hondalus MK: Pathogenesis and virulence of Rhodococcus equi. Vet Microbiol 56:257, 1997. PUBMED Abstract
  16. Cohen ND, Smith KE, Ficht TA, et al: Epidemiologic study of results of pulsed-field gel electrophoresis of isolates of Rhodococcus equi obtained from horses and horse farms. Am J Vet Res 64:153, 2003. PUBMED Abstract
  17. Morton AC, Begg AP, Anderson GA, et al: Epidemiology of Rhodococcus equi strains of Thoroughbred horse farms. Appl Environ Microbiol 67:2167, 2001. PUBMED Abstract
  18. Bolton T, Kuskie K, Halbert N, et al: Detection of strain variation in isolates of Rhodococcus equi from an affected foal using repetitive sequence-based polymerase chain reaction. J Vet Diagn Invest 22:611, 2010. PUBMED Abstract
  19. Tkachuk-Saad O, Prescott JF: Rhodococcus equi plasmids: isolation and partial characterization. J Clin Microbiol 29:2696, 1991. PUBMED Abstract
  20. Takai S, Shoda M, Sasaki Y, et al: Restriction fragment length polymorphisms of virulence plasmids in Rhodococcus equi. J Clin Microbiol 37:3417, 1999. PUBMED Abstract
  21. Takai S, Murata N, Kudo R, et al: Two new variants of the Rhodococcus equi virulence plasmid, 90 kb type III and type IV, recovered from a foal in Japan. Vet Microbiol 82:373, 2001. PUBMED Abstract
  22. Takai S, Ogawa K, Fukunaga N, et al: Isolation of virulent Rhodococcus equi from native Japanese horses. Comp Immunol Microbiol Infect Dis 24:123, 2001. PUBMED Abstract
  23. Takai S, Son WG, Lee DS, et al: Rhodococcus equi virulence plasmids recovered from horses and their environment in Jeju, Korea: 90-kb type II and a new variant, 90-kb type V. J Vet Med Sci 65:1313, 2003. PUBMED Abstract
  24. Takai S, Chaffin MK, Cohen ND, et al: Prevalence of virulent Rhodococcus equi in soil from five R. equi–endemic horse-breeding farms and restriction fragment length polymorphisms of virulence plasmids in isolates from soil and infected foals in Texas. Vet Diagn Invest 13:489, 2001. PUBMED Abstract
  25. Makrai L, Takai S, Tamura M, et al: Characterization of virulence plasmid types in Rhodococcus equi isolates from foals, pigs, humans and soil in Hungary. Vet Microbiol 88:377, 2002. PUBMED Abstract
  26. Takai S, Henton MM, Picard JA, et al: Prevalence of virulent Rhodococcus equi in isolates from soil collected from two horse farms in South Africa and restriction fragment length polymorphisms of virulence plasmids in the isolates from infected foals, a dog and a monkey. Onderstepoort J Vet Res 68:105, 2001. PUBMED Abstract
  27. Ribeiro MG, Seki I, Yasuoka K, et al: Molecular epidemiology of virulent Rhodococcus equi from foals in Brazil: virulence plasmids of 85-kb type I, 87-kb type I, and a new variant, 87-kb type III. Comp Immunol Microbiol Infect Dis 28:53, 2005. PUBMED Abstract
  28. Takai S, Hines SA, Sekizaki T, et al: DNA sequence and comparison of virulence plasmids from Rhodococcus equi ATCC 33701 and 103. Infect Immun 68:6840, 2000. PUBMED Abstract
  29. Letek M, Ocampo-Sosa AA, Sanders M, et al: Evolution of the Rhodococcus equi vap pathogenicity island seen through comparison of host-associated vapA and vapB virulence plasmids. J Bacteriol 190:5797, 2008. PUBMED Abstract
  30. Tan C, Prescott JF, Patterson MC, et al: Molecular characterization of a lipid-modified virulence associated protein of Rhodococcus equi and its potential in protective immunity. Can J Vet Res 59:5, 1995. PUBMED Abstract
  31. Byrne BA, Prescott JF, Palmer GH, et al: Virulence plasmid of Rhodococcus equi contains inducible gene family encoding secreted proteins. Infect Immun 69:650, 2001. PUBMED Abstract
  32. Jain S, Bloom BR, Hondalus MK: Deletion of vapA encoding virulence associated protein A attenuates the intracellular actinomycete Rhodococcus equi. Mol Microbiol 50:115, 2003. PUBMED Abstract
  33. Luhrmann A, Mauder N, Sydor T, et al: Necrotic death of Rhodococcus equi–infected macrophages is regulated by virulence-associated plasmids. Infect Immun 72:853, 2004. PUBMED Abstract
  34. Hondalus MK, Mosser DM: Survival and replication of Rhodococcus equi in macrophages. Infect Immun 62:4167, 1994. PUBMED Abstract
  35. Coulson GB, Agarwal S, Hondalus MK. Characterization of the role of the pathogenicity island and vapG in the virulence of the intracellular actinomycete pathogen Rhodococcus equi. Infect Immun 78:3323, 2010. PUBMED Abstract
  36. Von Bargen K, Polidori M, Becken U, et al: Rhodococcus equi virulence-associated protein A is required for diversion of phagosome biogenesis but not for cytotoxicity. Infect Immun 77:5676, 2009. PUBMED Abstract
  37. Ren J, Prescott JF: The effect of mutation on Rhodococcus equi virulence plasmid gene expression and mouse virulence. Vet Microbial 103:219, 2004. PUBMED Abstract
  38. Russell DA, Byrne GA, O'Connell EP, et al: The LysR-type transcriptional regulator VirR is required for expression of the virulence gene vapA of Rhodococcus equi, ATCC 33701. J Bacteriol 186:5576, 2004. PUBMED Abstract
  39. Miranda-Casoleuengo R, Mirando-Casoluengo AA, O'Connell EP, et al: The vapA co-expressed virulence plasmid gene vcgB (orf10) of the intracellular actinomycete Rhodococcus equi. Microbiology 157:2357, 2011.
  40. Letek M, Gonzalez P, Macarthur I, et al: The genome of a pathogenic Rhodococcus: co-optive virulence underpinned by key gene acquisitions. PLoS Genet 6:e1001145, 2010. PUBMED Abstract
  41. Jordan MC, Harrington JR, Cohen ND, et al: Effects of iron modulation on growth and viability of Rhodococcus equi and expression of virulence-associated protein A. Am J Vet Res 64:1337, 2003. PUBMED Abstract
  42. Wall DM, Duffy PS, Dupont C, et al: Isocitrate lyase activity is required for virulence of the intracellular pathogen Rhodococcus equi. Infect Immun 73:6736, 2005. PUBMED Abstract
  43. Macarthur I, Parreira VR, Lepp D, et al: The sensor kinase MprB is required for Rhodococcus equi virulence. Vet Microbiol 147:133, 2011. PUBMED Abstract
  44. Pei Y, Parreira V, Nicholson VM, et al: Mutation and virulence assessment of chromosomal genes of Rhodococcus equi 103. Can J Vet Res 71:1, 2007. PUBMED Abstract
  45. Muscatello G, Leadon DP, Klayt M, et al: Rhodococcus equi infection in foals: the science of “rattles”. Equine Vet J 39:470, 2007. PUBMED Abstract
  46. Gotoh K, Mitsuyama M, Imaizumi S, et al: Mycolic acid–containing glycolipid as a possible virulence factor of Rhodococcus equi for mice. Microbiol Immunol 35:175, 1991. PUBMED Abstract
  47. Sydor T, von Bargen K, Becken U, et al: A mycolyl transferase mutant of Rhodococcus equi lacking capsule integrity is fully virulent. Vet Microbiol 128:327, 2008. PUBMED Abstract
  48. Martens RJ, Takai S, Cohen ND, et al: Association of disease with isolation and virulence of Rhodococcus equi from farm soil and foals with pneumonia. J Am Vet Med Assoc 217:220, 2000. PUBMED Abstract
  49. Nordmann P, Zinzendorf N, Keller M, et al: Interaction of virulent and non-virulent Rhodococcus equi human isolates with phagocytes, fibroblast- and epithelial-derived cells. FEMS Immunol Med Microbiol 9:199, 1994. PUBMED Abstract
  50. Nordmann P, Keller M, Espinasse F, et al: Correlation between antibiotic resistance, phage-like particle presence, and virulence in Rhodococcus equi human isolates. J Clin Microbiol 32:377, 1994. PUBMED Abstract
  51. Takai S, Iie M, Watanabe Y, et al: Virulence-associated 15- to 17-kilodalton antigens in Rhodococcus equi: temperature-dependent expression and location of the antigens. Infect Immun 60:2995, 1992. PUBMED Abstract
  52. Takai S, Fukunaga N, Kamisawa K, et al: Expression of virulence-associated antigens of Rhodococcus equi is regulated by temperature and pH. Microbiol Immunol 40:591, 1996. PUBMED Abstract
  53. Benoit S, Benachour A, Taouji S, et al: Induction of vap genes encoded by the virulence plasmid of Rhodococcus equi during acid tolerance response. Res Microbiol 152:439, 2001. PUBMED Abstract
  54. Benoit S, Benachour A, Taouji S, et al: H2O2, which causes macrophage-related stress, triggers induction of expression of virulence-associated plasmid determinants in Rhodococcus equi. Infect Immun 70:3768, 2002. PUBMED Abstract
  55. Ren J, Prescott JF: Analysis of virulence plasmid gene expression of intra-macrophage and in vitro Rhodococcus equi ATCC 33701. Vet Microbiol 94:167, 2003. PUBMED Abstract
  56. Haites RE, Muscatello G, Begg AP, et al: Prevalence of the virulence-associated gene of Rhodococcus equi in isolates from infected foals. J Clin Microbiol 35:1642, 1997. PUBMED Abstract
  57. Takai S, Martens RJ, Julian A, et al: Virulence of Rhodococcus equi isolated from cats and dogs. J Clin Microbiol 41:4468, 2003. PUBMED Abstract
  58. Flynn O, Quigley F, Costello E, et al: Virulence-associated protein characterisation of Rhodococcus equi isolated from bovine lymph nodes. Vet Microbiol 78:221, 2001. PUBMED Abstract
  59. Tkachuk-Saad O, Lusis P, Welsch RD, et al: Rhodococcus equi infection in goats. Vet Rec 143:311, 1998. PUBMED Abstract
  60. Takai S, Imai Y, Fukunaga N, et al: Identification of virulence-associated antigens and plasmids in Rhodococcus equi from patients with AIDS. J Infect Dis 172:1306, 1995. PUBMED Abstract
  61. Takai S, Fukunaga N, Ochiai S, et al: Identification of intermediately virulent Rhodococcus equi isolates from pigs. J Clin Microbiol 34:1034, 1996. PUBMED Abstract
  62. Takai S, Anzai T, Fujita Y, et al: Pathogenicity of Rhodococcus equi expressing a virulence-plasmid associated 20 kDa protein (VapB) in foals. Vet Microbiol 76:71, 2000. PUBMED Abstract
  63. Pate M, Zdova I, Pirs T, et al: Isolation and characterisation of Mycobacterium avium and Rhodococcus equi from granulomatous lesions of swine lymph nodes in Slovenia. Acta Vet Hung 52:143, 2004. PUBMED Abstract
  64. Weinstock DM, Brown AE: Rhodococcus equi: an emerging pathogen. Clin Infect Dis 34:1379, 2002. PUBMED Abstract
  65. Barton MD, Hughes KL: Ecology of Rhodococcus equi. Vet Microbiol 9:65, 1984. PUBMED Abstract
  66. Woolcock JB, Mutimer MD, Farmer AM: Epidemiology of Corynebacterium equi in horses. Res Vet Sci 28:87, 1980. PUBMED Abstract
  67. Debey MC, Bailie WE: Rhodococcus equi in fecal and environmental samples from Kansas horse farms. Vet Microbiol 14:251, 1987. PUBMED Abstract
  68. Prescott JF: Epidemiology of Rhodococcus equi infection in horses. Vet Microbiol 14:211, 1987. PUBMED Abstract
  69. Sanada Y, Noda H, Nagahata H: Serological survey of Rhodococcus equi infection in horses in Hokkaido. J Vet Med Sci 54:649, 1992. PUBMED Abstract
  70. Takai S, Syakalima M, Yasuda J, et al: Isolation of Rhodococcus equi from the feces of indigenous animals and soil from the Lower Zambezi National Park and Lochinvar National Park, Zambia. J Vet Med Sci 66:743, 2004. PUBMED Abstract
  71. Takai S, Sengee S, Madarame H, et al: The absence of Rhodococcus equi in Mongolian horses. J Vet Med Sci 67:611, 2005. PUBMED Abstract
  72. Takai S: Epidemiology of Rhodoccoccus equi infections: a review. Vet Microbiol 56:167, 1997. PUBMED Abstract
  73. Takai S, Fujimori T, Katsuzaki K, et al: Ecology of Rhodococcus equi in horses and their environment on horse-breeding farms. Vet Microbiol 14:233, 1987. PUBMED Abstract
  74. Takai S, Narita K, Ando K, et al: Ecology of Rhodococcus (Corynebacterium) equi in soil on a horse-breeding farm. Vet Microbiol 12:169, 1986. PUBMED Abstract
  75. Takai S, Ohbushi S, Koike K, et al: Prevalence of virulent Rhodococcus equi in isolates from soil and feces of horses from horse-breeding farms with and without endemic infections. J Clin Microbiol 29:2887, 1991. PUBMED Abstract
  76. Takai S, Ohkura H, Watanabe Y, et al: Quantitative aspects of fecal Rhodococcus (Corynebacterium) in foals. J Clin Microbiol 23:794, 1986. PUBMED Abstract
  77. Muscatello G, Church S, Whithear KG, et al: Virulent Rhodococcus equi on horse farms: source and spread of rattles. In Proceedings of the Workshop on Rhodococcus equi and Equine Rhodococcal Pneumonia, 2002, p 5.
  78. Giguere S: Recent developments in the control and therapy of Rhodococcus equi infections in foals, Proc ACVIM, 2001, p 173.
  79. Martens RJ, Tiske RA, Renshaw HW: Experimental subacute foal pneumonia induced by aerosol administration of Corynebacterium equi. Equine Vet J 14:11, 1983.
  80. Johnson JA, Prescott JF, Markham RJ: The pathology of experimental Corynebacterium equi infection in foals following intrabronchial challenge. Vet Pathol 20:440, 1983. PUBMED Abstract
  81. Wada R, Kamada M, Anzai T, et al: Pathogenicity and virulence of Rhodococcus equi in foals following intratracheal challenge. Vet Microbiol 56:301, 1997. PUBMED Abstract
  82. Muscatello G, Anderson GA, Gilkerson JR, et al: Associations between the ecology of virulent Rhodococcus equi and the epidemiology of R. equi pneumonia on Australian thoroughbred farms. Appl Environ Microbiol 72:6152, 2006. PUBMED Abstract
  83. Muscatello G, Gilkerson JR, Browning GF: Effects of selective intensive irrigation on the incidence and prevalence of Rhodococcus equi pneumonia on an endemically affected farm. Aust Equine Vet 25:79, 2006.
  84. Muscatello G, Gerbaud S, Kennedy C, et al: Comparison of concentrations of Rhodococcus equi and virulent R. equi in air of stables and paddocks on horse breeding farms in a temperate climate. Equine Vet J 38:263, 2006. PUBMED Abstract
  85. Kuskie KR, Smith JL, Wang N, et al: Effects of location for collection of air samples on a farm and time of day of sample collection on airborne concentrations of virulent Rhodococcus equi at two horse breeding farms. Am J Vet Res 72:73, 2011. PUBMED Abstract
  86. Johnson JA, Prescott JF, Markham RJ: The pathology of experimental Corynebacterium equi infection in foals following intragastric challenge. Vet Pathol 20:450, 1982.
  87. Prescott JF, Johnson JA, Markham RJF: Experimental studies on the pathogenesis of Corynebacterium infection in foals. Can J Comp Med 44:280, 1980. PUBMED Abstract
  88. Smith BP, Jang SS: Isolation of Corynebacterium from a foal with an ulcerated leg wound and a pectoral abscess. J Am Vet Med Assoc 177:623, 1980. PUBMED Abstract
  89. Perdrizet JA, Scott DW: Cellulitis and subcutaneous abscesses caused by Rhodococcus equi infection in a foal. J Am Vet Med Assoc 190:1559, 1987. PUBMED Abstract
  90. Barton MD, Embury OH: Studies of the pathogenesis of Rhodococcus equi infection in foals. Aust Vet J 64:332, 1987. PUBMED Abstract
  91. Yager JA: The pathogenesis of Rhodococcus equi pneumonia in foals. Vet Microbiol 14:225, 1987. PUBMED Abstract
  92. Horowitz ML, Cohen ND, Takai S, et al: Application of Sartwell's model (lognormal distribution of incubation periods) to age at onset and age at death of foals with Rhodococcus equi pneumonia as evidence of perinatal infection. J Vet Intern Med 15:171, 2001. PUBMED Abstract
  93. Giguere S, Gaskin JM, Miller C, et al: Evaluation of a commercially available hyperimmune plasma product for prevention of naturally acquired pneumonia caused by Rhodococcus equi in foals. J Am Vet Med Assoc 220:59, 2002. PUBMED Abstract
  94. Chaffin MK, Cohen ND, Martens RJ, et al: Evaluation of the efficacy of gallium maltolate for chemoprophylaxis against pneumonia caused by Rhodococcus equi infection in foals. Am J Vet Res 72:945, 2011. PUBMED Abstract
  95. Hooper-McGrevy K, Prescott JF: Is fatal Rhodococcus equi pneumonia of foals only an infection acquired by the perinate? J Vet Intern Med 15:169, 2001. PUBMED Abstract
  96. Giguere S, Jacks S, Roberts GD, et al: Retrospective comparison of azithromycin, clarithromycin, and erythromycin for the treatment of foals with Rhodococcus equi pneumonia. J Vet Intern Med 18:568, 2004. PUBMED Abstract
  97. Martens RJ, Cohen ND, Chaffin MK, et al: Association of pneumonia in foals caused by Rhodococcus equi with farm soil geochemistry. Am J Vet Res 63:95, 2002. PUBMED Abstract
  98. Madigan JE, Hietala S, Muller N: Protection against naturally acquired Rhodococcus equi pneumonia in foals by administration of hyperimmune plasma. J Reprod Fertil Suppl 44:571, 1991. PUBMED Abstract
  99. Higuchi T, Arakawa T, Hashikura S, et al: Effect of prophylactic administration of hyperimmune plasma to prevent Rhodococcus equi infection on foals from endemically infected farms. Zentralbl Veterinarmed B 46:641, 1999. PUBMED Abstract
  100. Giguere S, Prescott JF: Clinical manifestations, diagnosis, treatment, and prevention of Rhodococcus equi infections in foals. Vet Microbiol 56:313, 1997. PUBMED Abstract
  101. Sweeney CR, Sweeney RW, Divers TJ: Rhodococcus equi pneumonia in 48 foals: response to antimicrobial therapy. Vet Microbiol 14:329, 1987. PUBMED Abstract
  102. Hillidge CJ: Use of erythromycin-rifampin combination in treatment of Rhodococcus equi pneumonia. Vet Microbiol 14:337, 1987. PUBMED Abstract
  103. Chaffin MK, Cohen ND, Martens RJ, et al: Foal-related risk factors associated with development of Rhodococcus equi pneumonia on farms with endemic infection. J Am Vet Med Assoc 223:1791, 2003. PUBMED Abstract
  104. Cohen ND, O'Conor MS, Chaffin MK, et al: Farm characteristics and management practices associated with development of Rhodococcus equi pneumonia in foals. J Am Vet Med Assoc 226:404, 2005. PUBMED Abstract
  105. Chaffin MK, Cohen ND, Martens RJ: Evaluation of equine breeding farm characteristics as risk factors for development of Rhodococcus equi pneumonia in foals. J Am Vet Med Assoc 222:467, 2003. PUBMED Abstract
  106. Chaffin MK, Cohen ND, Martens RJ: Evaluation of equine breeding farm management and preventative health practices as risk factors for development of Rhodococcus equi pneumonia in foals. J Am Vet Med Assoc 222:476, 2003. PUBMED Abstract
  107. Knottenbelt DC: Rhodococcus equi infection in foals: a report of an outbreak on a Thoroughbred stud in Zimbabwe. Vet Rec 132:79, 1993. PUBMED Abstract
  108. Prescott JF: Rhodococcus equi: an animal and human pathogen. Clin Microbiol Rev 4:20, 1991. PUBMED Abstract
  109. Prescott JF, Travers M, Yager-Johnson JA: Epidemiological survey of Corynebacterium equi infections on five Ontario horse farms. Can J Comp Med 48:10, 1984. PUBMED Abstract
  110. Robinson RC: Epidemiological and bacteriological studies of Corynebacterium equi isolated from California farms. J Reprod Fertil Suppl 32:477, 1982. PUBMED Abstract
  111. Cohen ND, Carter CN, Scott HM, et al: Association of soil concentrations of Rhodococcus equi and incidence of pneumonia attributable to Rhodococcus equi in foals on farms in central Kentucky. Am J Vet Res 69:385, 2008. PUBMED Abstract
  112. Grimm MB, Cohen ND, Slovis NM, et al: Evaluation of fecal samples from mares as a source of Rhodococcus equi for their foals by use of quantitative bacteriologic culture and colony immunoblot analyses. Am J Vet Res 68:63, 2007. PUBMED Abstract
  113. Chaffin MK, Cohen ND, Martens RJ, et al: Hematologic and immunophenotypic factors associated with development of Rhodococcus equi pneumonia of foals at equine breeding farms with endemic infections. Vet Immunol Immunopathol 100:33, 2004. PUBMED Abstract
  114. Flaminio MJ, Rush BR, Shuman W: Peripheral blood lymphocyte subpopulations and immunoglobulin concentrations in healthy foals and foals with Rhodoccus equi pneumonia. J Vet Intern Med 13:206, 1999. PUBMED Abstract
  115. Mousel MR, Harrison L, Donahue JM, et al: Rhodococcus equi and genetic susceptibility: assessing transferrin genotypes from paraffin-embedded tissues. J Vet Diagn Invest 15:470, 2003. PUBMED Abstract
  116. Nordengrahn A, Rusvai M, Merza M, et al: Equine herpesvirus type 2 (EHV-2) as a predisposing factor for Rhodococcus equi pneumonia in foals: prevention of the bifactorial disease with EHV-2 immunostimulating complexes. Vet Microbiol 51:55, 1996. PUBMED Abstract
  117. Palfi V, Belak S, Molnar T: Isolation of equine herpesvirus type 2 from foals showing respiratory symptoms. Zbl Vet Med B 25:165, 1978. PUBMED Abstract
  118. Muscatello G: Rhodococcus equi pneumonia in the foal—Part 1: pathogenesis and epidemiology. Vet J 192:20, 2012. PUBMED Abstract
  119. Toyooka K, Takai S, Kirikae T: Rhodococcus equi can survive a phagolysosomal environment in macrophages by suppressing acidification of the phagolysosome. J Med Microbiol 54:1007, 2005. PUBMED Abstract
  120. Hondalus MK, Diamond MS, Rosenthal LA, et al: The intracellular bacterium Rhodococcus equi requires Mac-1 to bind to mammalian cells. Infect Immun 61:2919, 1993. PUBMED Abstract
  121. Ellenberger MA, Kaeberle ML, Roth JA: Effect of Rhodococcus equi on equine polymorphonuclear leukocyte function. Vet Immunol Immunopathol 7:315, 1984. PUBMED Abstract
  122. Aderem A, Underhill DM: Mechanisms of phagocytosis in macrophages. Ann Rev Immunol 17:593, 1999. PUBMED Abstract
  123. Brumbaugh GW, Davis LE, Thurmon JC, et al: Influence of Rhodococcus equi on the respiratory burst of resident alveolar macrophages from adult horses. Am J Vet Res 51:766, 1990. PUBMED Abstract
  124. Hietala SK, Ardans AA: Interaction of Rhodococcus equi with phagocytic cells from R. equi–exposed and non-exposed foals. Vet Microbiol 14:307, 1987. PUBMED Abstract
  125. Zink MC, Yager JA, Prescott JF, et al: Electron microscopic investigation of intracellular events after ingestion of Rhodococcus equi by foal alveolar macrophages. Vet Microbiol 14:295, 1987. PUBMED Abstract
  126. Dawson TR, Nydam DV, Price CT, et al: Effects of opsonization of Rhodococcus equi on bacterial viability and phagocyte activation. Am J Vet Res 72:1465, 2011. PUBMED Abstract
  127. Garton NJ, Gilleron M, Brando T, et al: A novel lipoarabinomannan from the equine pathogen Rhodococcus equi. Structure and effect on macrophage cytokine production. J Biol Chem 277:31722, 2002. PUBMED Abstract
  128. Sweet L, Singh PP, Azad AK, et al: Mannose receptor-dependent delay in phagosome maturation by Mycobacterium avium glycopeptidolipids. Infect Immun 78:518, 2010. PUBMED Abstract
  129. Fernandez-Mora E, Polidori M, Luhrmann A, et al: Maturation of Rhodococcus equi–containing vacuoles is arrested after completion of the early endosome stage. Traffic 6:635, 2005. PUBMED Abstract
  130. Von Bargen K, Wohlmann J, Taylor GA, et al: Nitric oxide-mediated intracellular growth restriction of pathogenic Rhodococcus equi can be prevented by iron. Infect Immun 79:2098, 2011. PUBMED Abstract
  131. Giguere S, Prescott JF: Cytokine induction in murine macrophages infected with virulent and avirulent Rhodococcus equi. Infect Immun 66:1848, 1998. PUBMED Abstract
  132. Bidaud P, Hebert L, Barbey C, et al: Rhodococcus equi's extreme resistance to hydrogen peroxide is mainly conferred by one of its four catalase genes. PLoS One 7:e42396, 2012. PUBMED Abstract
  133. Flynn JL, Chan J: What's good for the host is good for the bug. Trends Microbiol 13:98, 2005. PUBMED Abstract
  134. Dawson TR, Horohov OW, Meijer WG, et al: Current understanding of the equine immune response to Rhodococcus equi. An immunological review of R. equi pneumonia. Vet Immunol Immunopathol 135:1, 2010. PUBMED Abstract
  135. Giguere S, Cohen ND, Chaffin MK, et al: Rhodococcus equi: clinical manifestations, virulence, and immunity. J Vet Intern Med 25:1221, 2011. PUBMED Abstract
  136. Darrah PA, Monaco MC, Jain S, et al: Innate immune responses to Rhodococcus equi. J Immunol 173:1914, 2004. PUBMED Abstract
  137. Heller MC, Jackson KA, Watson JL: Identification of immunologically relevant genes in mare and foal dendritic cells responding to infection by Rhodococcus equi. Vet Immunol Immunopathol 136:144, 2010. PUBMED Abstract
  138. Darrah PA, Hondalus MK, Chen Q, et al: Cooperation between reactive oxygen and nitrogen intermediates in killing of Rhodococcus equi by activated macrophages. Infect Immun 68:3587, 2000. PUBMED Abstract
  139. Ferraz LC, Bernades ES, Oliveira AF, et al: Lack of galectin-3 alters the balance of innate immune cytokines and confers resistance to Rhodococcus equi infection. Eur J Immunol 38:2762, 2008. PUBMED Abstract
  140. Nerren JR, Payne S, Halbert ND, et al: Cytokine expression by neutrophils of adult horses stimulated with virulent and avirulent Rhodococcus equi in vitro. Vet Immunol Immunopathol 127:135, 2009. PUBMED Abstract
  141. Martens RJ, Cohen ND, Jones SL, et al: Protective role of neutrophils in mice experimentally infected with Rhodococcus equi. Infect Immun 73:7040, 2005. PUBMED Abstract
  142. Yager JA, Foster SF, Zink MC, et al: In vitro bactericidal efficacy of equine polymorphonuclear leukocytes against Corynebacterium equi. Am J Vet Res 47:438, 1986. PUBMED Abstract
  143. Martens JG, Martens RJ, Renshaw HW: Rhodococcus (Corynebacterium) equi: bactericidal capacity of neutrophils from neonatal and adult horses. Am J Vet Res 49:295, 1988. PUBMED Abstract
  144. Martens RJ, Martens JG, Renshaw HW, et al: Rhodococcus equi: equine neutrophil chemiluminescent and bactericidal responses to opsonizing antibody. Vet Microbiol 14:277, 1987. PUBMED Abstract
  145. Nerren JR, Martens RI, Payne S, et al: Age-related changes in cytokine expression by neutrophils of foals stimulated with virulent Rhodococcus equi in vitro. Vet Immunol Immunopathol 127:212, 2009. PUBMED Abstract
  146. Liu M, Liu T, Bordin A, et al: Activation of foal neutrophils at different ages by CpG oligodeoxynucleotides and Rhodococcus equi. Cytokine 48:280, 2009. PUBMED Abstract
  147. Hines SA, Kanaly ST, Byrne BA, et al: Immunity to Rhodococcus equi. Vet Microbiol 56:177, 1997. PUBMED Abstract
  148. Takai S, Kawazu S, Tsubaki S: Immunoglobulin and specific antibody responses to Rhodococcus (Corynebacterium) equi infection in foals as measured by enzyme-linked immunosorbent assay. J Clin Microbiol 23:943, 1986. PUBMED Abstract
  149. Ellenberger MA, Kaeberle ML, Roth JA: Equine humoral immune response to Rhodococcus (Corynebacterium) equi. Am J Vet Res 45:2428, 1984. PUBMED Abstract
  150. Takai S, Hidaka D, Fujii M, et al: Serum antibody responses of foals to virulence associated 15- to 17-kilodalton antigens of Rhodococcus equi. Vet Microbiol 52:63, 1996. PUBMED Abstract
  151. Hietala SK, Ardans AA, Sansome A: Detection of Corynebacterium equi–specific antibody in horses by enzyme-linked immunosorbent assay. Am J Vet Res 46:13, 1985. PUBMED Abstract
  152. Lopez AM, Hines MT, Palmer GH, et al: Identification of pulmonary T-lymphocyte and serum antibody isotype responses associated with protection against Rhodococcus equi. Clin Diagn Lab Immunol 9:1270, 2002. PUBMED Abstract
  153. Nordmann P, Ronco E, Nauciel C: Role of T-lymphocyte subsets in Rhodococcus equi infection. Infect Immun 60:2748, 1992. PUBMED Abstract
  154. Fernandez AS, Prescott JF, Nicholson VM: Protective effect against Rhodococcus equi infection in mice of IgG purified from horses vaccinated with virulence associated protein (VapA)–enriched antigens. Vet Microbiol 56:187, 1997. PUBMED Abstract
  155. Martens RJ, Martens JG, Fiske RA: Rhodococcus equi foal pneumonia: protective effects of immune plasma in experimentally infected foals. Equine Vet J 21:249, 1989. PUBMED Abstract
  156. Chaffin MK, Martens RJ, Martens JG: Therapeutic effects of immune plasma in foals with Rhodococcus equi pneumonia. Equine Vet J Suppl 21:23, 1991.
  157. Perkins GA, Yeager A, Erb HN, et al: Survival of foals with experimentally induced Rhodococcus equi infection given either hyperimmune plasma containing R. equi antibody or normal equine plasma. Vet Ther 2:334, 2001.
  158. Prescott JF, Nicholson VM, Patterson MC, et al: Use of Rhodococcus equi virulence-associated protein for immunization of foals against R. equi pneumonia. Am J Vet Res 58:356, 1997. PUBMED Abstract
  159. Hurley JR, Begg AP: Failure of hyperimmune plasma to prevent pneumonia caused by Rhodococcus equi in foals. Aust Vet J 72:418, 1995. PUBMED Abstract
  160. Caston SS, McClure SR, Martens RJ, et al: Effect of hyperimmune plasma on the severity of pneumonia caused by Rhodococcus equi in experimentally infected foals. Vet Ther 7:361, 2006. PUBMED Abstract
  161. Hooper-McGrevy KE, Giguere S, Wilkie BN, et al: Evaluation of equine immunoglobulin specific for Rhodococcus equi virulence-associated proteins A and C for use in protecting foals against Rhodococcus equi–induced pneumonia. Am J Vet Res 62:1307, 2001. PUBMED Abstract
  162. Martens RJ, Martens JG, Fiske RA: Failure of passive immunisation by colostrum from immunised mares to protect foals against Rhodococcus equi pneumonia. Equine Vet J Suppl 21:19, 1991.
  163. Cauchard J, Sevin C, Ballet JJ, et al: Foal IgG and opsonizing anti-Rhodococcus equi antibodies after immunization of pregnant mares with a protective VapA candidate vaccine. Vet Microbiol 104:73, 2004. PUBMED Abstract
  164. Kanaly ST, Hines SA, Palmer GH: Failure of pulmonary clearance of Rhodococcus equi infection in CD4+ T-lymphocyte-deficient transgenic mice. Infect Immun 61:4929, 1993 PUBMED Abstract
  165. Kanaly ST, Hines SA, Palmer GH: Cytokine modulation alters pulmonary clearance of Rhodococcus equi and development of granulomatous pneumonia. Infect Immun 63:3037, 1995. PUBMED Abstract
  166. Kanaly ST, Hines SA, Palmer GH: Transfer of a CD4+ Th1 cell line to nude mice effects clearance of Rhodococcus equi from the lung. Infect Immun 64:1126, 1996. PUBMED Abstract
  167. Colonna M: Can we apply the Th1-Th2 paradigm to all lymphocytes? Nat Immunol 2:899, 2001. PUBMED Abstract
  168. Ottenhoff TH: New pathways of protective and pathological host defense to mycobacteria. Trends Microbiol 20:419, 2012. PUBMED Abstract
  169. Lindenstrom T, Woodworth J, Dietrich J, et al: Vaccine-induced Th17 cells are maintained long-term post-vaccination as a distinct and phenotypically stable memory subset. Infect Immun epub Jul 30, 2012. PUBMED Abstract
  170. Liu M, Bordin A, Liu T, et al: Gene expression of innate Th1-, Th2-, and Th17-type cytokines during early life of neonatal foals in response to Rhodococcus equi. Cytokine 56:356, 2011. PUBMED Abstract
  171. Canaday DH, Wilkinson RJ, Li Q, et al: CD4+ and CD8+ T cells kill intracellular Mycobacterium tuberculosis by a perforin and Fas/Fas ligand–independent mechanism. J Immunol 167:2734, 2001. PUBMED Abstract
  172. Serbina NV, Liu CC, Scanga CA, et al: CD8+ CTL from lungs of Mycobacterium tuberculosis–infected mice express perforin in vivo and lyse infected macrophages. J Immunol 165:353, 2000. PUBMED Abstract
  173. Hines MT, Paasch KM, Alperin DC, et al: Immunity to Rhodococcus equi: antigen-specific recall responses in the lungs of adult horses. Vet Immunol Immunopathol 79:101, 2001. PUBMED Abstract
  174. Patton KM, McGuire TC, Fraser DG, et al: Rhodococcus equi–infected macrophages are recognized and killed by CD8+ T lymphocytes in a major histocompatibility complex class I–unrestricted fashion. Infect Immun 72:7073, 2004. PUBMED Abstract
  175. Harris SP, Fujiwara N, Mealey RH, et al: Identification of Rhodococcus equi lipids recognized by host cytotoxic T lymphocytes. Microbiology 156:1836, 2010. PUBMED Abstract
  176. Adkins B, Bu Y, Guevara P: The generation of Th memory in neonates versus adults: prolonged primary Th2 effector function and impaired development of Th1 memory effector function in murine neonates. J Immunol 166:918, 2001. PUBMED Abstract
  177. Siegrist CA: Neonatal and early life vaccinology. Vaccine 19:3331, 2001. PUBMED Abstract
  178. Morein B, Abusugra I, Blomqvist G: Immunity in neonates. Vet Immunol Immunopathol 87:207, 2002. PUBMED Abstract
  179. Boyd NK, Cohen ND, Lim WS, et al: Temporal changes in cytokine expression of foals during the first month of life. Vet Immunol Immunopathol 92:75, 2003. PUBMED Abstract
  180. Adkins B, Leclerc C, Marshall-Clarke: Neonatal adaptive immunity comes of age. Nat Rev 4:553, 2004. PUBMED Abstract
  181. Flaminio MJ, Nydam D, Marquis H, et al: Foal monocyte-derived dendritic cells become activated upon Rhodococcus equi infection. Clin Vaccine Immunol 16:176, 2009. PUBMED Abstract
  182. Pargass IS, Wills TB, Davis WC, et al: The influence of age and Rhodococcus equi infection on CD1 expression by equine antigen presenting cells. Vet Immunol Immunopathol 130:197, 2009. PUBMED Abstract
  183. Patton KM, McGuire TC, Hines MT, et al: Rhodococcus equi-specific cytotoxic T lymphocytes in immune horses and development in asymptomatic foals. Infect Immun 73:2083, 2005. PUBMED Abstract
  184. Harris SP, Hines MT, Mealey RH, et al: Early development of cytotoxic T lymphocytes in neonatal foals following oral inoculation with Rhodococcus equi. Vet Immunol Immunopathol 14:312, 2011. PUBMED Abstract
  185. Breathnach CC, Sturgill-Wright T, Stiltner JL, et al: Foals are interferon gamma-deficient at birth. Vet Immunol Immunopathol 112:199, 2006. PUBMED Abstract
  186. Sponseller BA, De Macedo MM, Clark SK, et al: Activation of peripheral blood monocytes results in more robust production of IL-10 in neonatal foals compared to adult horses. Vet Immunol Immunopathol 127:167, 2009. PUBMED Abstract
  187. Liu T, Nerren J, Liu M, et al: Basal and stimulus-induced cytokine expression is selectively impaired in peripheral blood mononuclear cells of newborn foals. Vaccine 27:674, 2009. PUBMED Abstract
  188. Wagner B, Burton A, Ainsworth D: Interferon-gamma, interleukin-4 and interleukin-10 production of T helper cells reveals intact Th1 and regulatory TR1 cell activation and a delay of the Th2 cell response in equine neonates and foals. Vet Res 41:47, 2010. PUBMED Abstract
  189. Ryan C, Giguere S, Hagen J, et al: Effect of age and mitogen on the frequency of interleukin-4 and interferon gamma secreting cells in foals and adult horses as assessed by an equine-specific ELISPOT assay. Vet Immunol Immunopathol 133:66, 2010. PUBMED Abstract
  190. Ryan C, Giguere S: Equine neonates have attenuated humoral and cell-mediated immune responses to a killed adjuvanted vaccine compared to adult horses. Clin Vaccin Immunol 17:1896, 2010. PUBMED Abstract
  191. Jacks S, Giguere S, Crawford PC, et al: Experimental infection of neonatal foals with Rhodococcus equi triggers adult-like gamma interferon induction. Clin Vaccine Immunol 14:669, 2007. PUBMED Abstract
  192. Jacks S, Giguere S, Prescott JF: In vivo expression of and cell-mediated immune responses to the plasmid-encoded virulence-associated proteins of Rhodococcus equi in foals. Clin Vaccine Immunol 14:369, 2007. PUBMED Abstract
  193. Sturgill TL, Giguere S, Franklin RP, et al: Effects of inactivated parapoxvirus ovis on the cumulative incidence of pneumonia and cytokine secretion of foals on a farm with endemic infections caused by Rhodococcus equi. Vet Immunol Immunopathol 140:237, 2011. PUBMED Abstract
  194. Zink MC, Yager JA, Smart NL: Corynebacterium equi infections in horses, 1958-1984: a review of 131 cases. Can Vet J 27:213, 1986. PUBMED Abstract
  195. Lavoie JP, Fiset L, Laverty S: Review of 40 cases of lung abscesses in foals and adult horses. Equine Vet J 26:348, 1994. PUBMED Abstract
  196. Ainsworth DM, Weldon AD, Beck KA, et al: Recognition of Pneumocystis carinii in foals with respiratory distress. Equine Vet J 25:103, 1993. PUBMED Abstract
  197. Lakritz J, Wilson WD, Berry CR, et al: Bronchointerstitial pneumonia and respiratory distress in young horses: clinical, clinicopathologic, radiographic, and pathological findings in 23 cases (1984-1989). J Vet Intern Med 7:277, 1993. PUBMED Abstract
  198. Valdes A, Johnson JR: Septic pleuritis and abdominal abscess formation caused by Rhodococcus equi in a foal. J Am Vet Med Assoc 227:960, 2005. PUBMED Abstract
  199. Wion L, Perkins G, Ainsworth DM, et al: Use of computerised tomography to diagnose a Rhodococcus equi mediastinal abscess causing severe respiratory distress in a foal. Equine Vet J 33:523, 2001. PUBMED Abstract
  200. Chaffin MK, Martens RJ: Extrapulmonary disorders associated with Rhodococcus equi pneumonia in foals: retrospective study of 61 cases (1988-1996). Proc Am Assoc Equine Pract 43:79, 1997.
  201. Reuss SM, Chaffin MK, Cohen ND: Extrapulmonary disorders associated with Rhodococcus equi infection in foals: 150 cases (1987-2007). J Am Vet Med Assoc 235:855, 2009. PUBMED Abstract
  202. Bohn AA, Rothschild C: Peritoneal fluid from a febrile foal. Vet Clin Pathol 31:189, 2002. PUBMED Abstract
  203. Nay TS: Extra-pulmonary Rhodococcus equi in a Thoroughbred foal. Can Vet J 37:623, 1996. PUBMED Abstract
  204. Shimizu C, Shibahara T, Takei S, et al: Lawsonia intracellularis and virulent Rhodococcus equi infection in a thoroughbred colt. J Comp Pathol 143:303, 2010. PUBMED Abstract
  205. Kenney DG, Robbins SC, Prescott JF, et al: Development of reactive arthritis and resistance to erythromycin and rifampin in a foal during treatment for Rhodococcus equi pneumonia. Equine Vet J 25:246, 1994. PUBMED Abstract
  206. Madison JB, Scarratt KW: Immune-mediated polysynovitis in four foals. J Am Vet Med Assoc 192:1581, 1988. PUBMED Abstract
  207. Firth FC, Alley MR, Hodge H: Rhodococcus equi–associated osteomyelitis in foals. Aust Vet J 70:304, 1993. PUBMED Abstract
  208. Collatos C, Clark ES, Reef VB, et al: Septicemia, atrial fibrillation, cardiomegaly, left atrial mass, and Rhodococcus equi septic osteoarthritis in a foal. J Am Vet Med Assoc 197:1039, 1990. PUBMED Abstract
  209. Desjardins MR, Vachon AM: Surgical management of Rhodococcus equi metaphysitis in a foal. J Am Vet Med Assoc 197:608, 1990. PUBMED Abstract
  210. Platt H: Septicaemia in the foal: a review of 61 cases. Br Vet J 139:221, 1973. PUBMED Abstract
  211. Rooney JR: Corynebacterial infections in foals. Mod Vet Pract 47:43–45, 1966.
  212. Chaffin MK, Honnas CM, Crabill MR, et al: Cauda equina syndrome, diskospondylitis, and a paravertebral abscess caused by Rhodococcus equi in a foal. J Am Vet Med Assoc 206:215, 1995. PUBMED Abstract
  213. Giguere S, Lavoie JP: Rhodococcus equi vertebral osteomyelitis in 3 Quarter Horse colts. Equine Vet J 26:74, 1994. PUBMED Abstract
  214. Olchowy TWJ: Vertebral body osteomyelitis due to Rhodococcus equi in two Arabian foals. Equine Vet J 26:79, 1994.
  215. Janicek JC, Kramer J, Coates JR, et al: Intracranial abscess caused by Rhodococcus equi infection in a foal. J Am Vet Med Assoc 228:251, 2006. PUBMED Abstract
  216. Dewes HF: The association between weather, frenzied behaviour, percutaneous invasion by Strongyloides westeri larvae and Rhodococcus equi disease in foals. N Z Vet J 37:669, 1996.
  217. Freestone JF, Shoemaker S, McClure JJ: Pulmonary abscessation, hepatoencephalopathy and IgM deficiency associated with Rhodococcus equi in a foal. Aust Vet J 66:343, 1989. PUBMED Abstract
  218. Blogg JR, Barton MD, Graydon R, et al: Blindness caused by Rhodococcus equi infection in a foal. Equine Vet J Suppl 2:25, 1983.
  219. Johns IC, Desrochers A, Wotman KL, et al: Presumed immune-mediated hemolytic anemia in two foals with Rhodococcus equi infection. J Vet Emerg Crit Care 21:273, 2011. PUBMED Abstract
  220. Bain AM: Corynebacterium equi infections in the equine. Aust Vet J 39:116, 1963.
  221. Genetzky RM, Bettcher MP, Arp LH, et al: Corynebacterium equi infection in a mare. Mod Vet Pract 63:876, 1982.
  222. Ramachandra RN, Ravindranath N, Roa MS, et al: Isolation of Corynebacterium equi from two cases of equine abortion in mares. Indian Vet J 58:83, 1981.
  223. Fitzgerald SD, Yamini B: Rhodococcal abortion and pneumonia in an equine fetus. J Vet Diagn Invest 7:157, 1995. PUBMED Abstract
  224. Patterson-Kane JC, Donahue JM, Harrison LR: Placentitis, fetal pneumonia, and abortion due to Rhodococcus equi infection in a Thoroughbred. J Vet Diagn Invest 14:157, 2002. PUBMED Abstract
  225. Tengelsen LA, Yamini B, Mullaney TP, et al: A 12-year retrospective study of equine abortion in Michigan. J Vet Diagn Invest 9:303, 1997. PUBMED Abstract
  226. Giles RC, Donahue JM, Hong CB, et al: Causes of abortion, stillbirth, and perinatal death in horses: 3,527 cases (1986-1991). J Am Vet Med Assoc 203:1170, 1993. PUBMED Abstract
  227. Szeredi L, Molnar T, Giavits R, et al: Two cases of equine abortion caused by Rhodococcus equi. Vet Pathol 43:208, 2006. PUBMED Abstract
  228. Nakamura Y, Nishi H, Katayama Y, et al: Abortion in a throughbred mare associated with an infection with avirulent Rhodococcus equi. Vet Rec 161:342, 2007. PUBMED Abstract
  229. Roberts MC, Hodgson DR, Kelly WR: Corynebacterium infection in an adult horse. Aust Vet J 56:96, 1980. PUBMED Abstract
  230. Freestone JF, Hietala S, Moulton J, Vivrette S: Acquired immunodeficiency in a seven-year-old horse. J Am Vet Med Assoc 190:689, 1987. PUBMED Abstract
  231. Ozgur NY, Ikiz S, Bagcigil F, et al: Rhodococcus equi pneumonia in a mare in Turkey. Vet Rec 151:613, 2002. PUBMED Abstract
  232. Vengust M, Staemplfi H, Prescott JF: Rhodococcus equi pleuropneumonia in an adult horse. Can Vet J 43:706, 2002. PUBMED Abstract
  233. Clark-Price SC, Rush BR, Gaughan EM, et al: Osteomyelitis of the pelvis caused by Rhodococcus equi in a two-year old horse. J Am Vet Med Assoc 222:969, 2003. PUBMED Abstract
  234. Veronck F, Deprez P, Decostere A, et al: B and T cell suppression in an Arabian horse with Rhodococcus equi infection. Vet Rec 154:149, 2004. PUBMED Abstract
  235. Morresey PR, Waldridge BM: Successful treatment of Rhodococcus pneumonia in an adult horse. J Vet Intern Med 24:436, 2010. PUBMED Abstract
  236. Giguere S, Cohen N, Chaffin MK, et al: Diagnosis, treatment, control and prevention of infections caused by Rhodococcus equi in foals. J Vet Intern Med 25:1209, 2011. PUBMED Abstract
  237. Anzai T, Wada R, Nakanishi A, et al: Comparison of tracheal aspiration with other tests for diagnosis of Rhodococcus equi pneumonia in foals. Vet Microbiol 56:335, 1997. PUBMED Abstract
  238. Sonmez K, Gurel A, Takai S: Immunocytochemical detection of Rhodococcus equi in tracheal washes of foals. J Comp Pathol 145:6, 2011. PUBMED Abstract
  239. Hashikura S, Higuchi T, Taharaguchi S, et al: Evaluation of nasotracheal aspiration as a diagnositic tool for Rhodococcus equi pneumonia in foals. Equine Vet J 32:560, 2000. PUBMED Abstract
  240. Sellon DC, Besser TE, Vivrette SL, et al: Comparison of nucleic acid amplification, serology, and microbiologic culture for diagnosis of Rhodococcus equi pneumonia in foals. J Clin Microbiol 39:1289, 2001. PUBMED Abstract
  241. Leadon D, Farrelly B, Fogarty U, et al: Platelet counting in diagnosis of Rhodococcus equi. Vet Rec 123:279, 1988. PUBMED Abstract
  242. Donisi A, Suardi MG, Casari S, et al: Rhodococcus equi infection in HIV-infected patients. AIDS 10:359, 1996. PUBMED Abstract
  243. Prescott JF, Hoffman AM: Rhodococcus equi. Vet Clin North Am Equine Pract 9:375, 1993. PUBMED Abstract
  244. Muscatello G, Gilkerson JR, Browning GF: Comparison of two selective media for the recovery, isolation, enumeration and differentiation of Rhodococcus equi. Vet Microbiol 119:324, 2007. PUBMED Abstract
  245. Falcon J, Smith BP, O'Brien TR, et al: Clinical and radiological findings in Corynebacterium equi pneumonia of foals. J Am Vet Med Assoc 186:593, 1985. PUBMED Abstract
  246. Higuchi T, Hashikura S, Hagiwara S, et al: Isolation of virulent Rhodococcus equi from transtracheal aspirates of foals serodiagnosed by enzyme-linked immunosorbent assay. J Vet Med Sci 59:1097, 1997. PUBMED Abstract
  247. Takai S, Morishita T, Nishio Y, et al: Evaluation of a monoclonal antibody–based colony blot test for rapid identification of virulent Rhodococcus equi. J Vet Med Sci 56:681, 1994. PUBMED Abstract
  248. Muller NS, Madigan JE: Methods of implementation of an immunoprophylaxis program for the prevention of Rhodococcus equi pneumonia: results of a 5-year field study. Proc Am Assoc Equine Pract 38:193, 1992.
  249. Giguere S, Hernandez J, Gaskin J, et al: Evaluation of white blood cell concentration, plasma fibrinogen concentration, and an agar gel immunodiffusion test for early identification of foals with Rhodococcus equi pneumonia. J Am Vet Med Assoc 223:1300, 2003. PUBMED Abstract
  250. Bell KS, Philip JC, Christofi N, et al: Identification of Rhodococcus equi using the polymerase chain reaction. Lett Appl Microbiol 23:72, 1996. PUBMED Abstract
  251. Sellon DC, Walker K, Suyemoto M, et al: Nucleic acid amplification for rapid detection of Rhodococcus equi in equine blood and tracheal wash fluids. Am J Vet Res 58:1232, 1997. PUBMED Abstract
  252. Takai S, Vigo G, Ikushima H, et al: Detection of virulent Rhodococcus equi in tracheal aspirate samples by polymerase chain reaction for rapid diagnosis of R. equi pneumonia in foals. Vet Microbiol 61:59, 1998. PUBMED Abstract
  253. Vivrette SL, Sellon DC, Gibbons DS: Clinical application of a polymerase chain reaction assay in the diagnosis of pneumonia caused by Rhodococcus equi in a horse. J Am Vet Med Assoc 217:1348, 2000. PUBMED Abstract
  254. Arriaga JM, Cohen ND, Derr JN, et al: Detection of Rhodococcus equi by polymerase chain reaction using species-specific nonproprietary primers. J Vet Clin Diagn Invest 14:347, 2002. PUBMED Abstract
  255. Ladron N, Fernandez M, Aguero J, et al: Rapid identification of Rhodococcus equi by a PCR assay targeting the choE gene. J Clin Microbiol 41:3241, 2003. PUBMED Abstract
  256. Halbert ND, Reitzel RA, Martens RJ, et al: Evaluation of a multiplex polymerase chain reaction assay for simultaneous detection of Rhodococcus equi and the vapA gene. Am J Vet Res 66:1380, 2005. PUBMED Abstract
  257. Harrington JR, Golding MC, Martens RJ, et al: Evaluation of a real-time quantitative polymerase chain reaction assay for detection and quantitation of virulent Rhodococcus equi. Am J Vet Res 66:755, 2005. PUBMED Abstract
  258. Rodriguez-Lazaro D, Lewis DA, Ocampo-Sosa AA, et al: Internally controlled real-time PCR method for quantitative species-specific detection and vapA genotyping of Rhodococcus equi. Appl Environ Microbiol 72:4256, 2006. PUBMED Abstract
  259. Monego F, Maboni F, Krewer C, et al: Molecular characterization of Rhodococcus equi from horse-breeding farms by means of multiplex PCR for the vap gene family. Curr Microbiol 58:399, 2009. PUBMED Abstract
  260. Venner M, Heyers P, Stutzberg-Minder K, Lorenz N, et al: Detection of Rhodococcus equi by microbiological culture and by polymerase chain reaction in samples of tracheobronchial secretions of foals. Berl Munch Tierarztl Wochenschr 120:126, 2007. PUBMED Abstract
  261. Ardans AA, Hietala SK, Spensley MS, et al: Studies of naturally occurring and experimental Rhodococcus equi (Corynebacterium equi) pneumonia in foals. Proc Am Assoc Equine Pract 32:129, 1986.
  262. Nakazawa M, Sugimoto C, Isayama Y: Quantitative culture of Rhodococcus equi from feces of horses. Natl Inst Anim Health Q (Jpn) 23:67, 1983. PUBMED Abstract
  263. Takai S, Iimori S, Tsubaki S: Quantitative fecal culture for early diagnosis of Corynebacterium (Rhodococcus) equi enteritis in foals. Can J Vet Res 50:479, 1986. PUBMED Abstract
  264. Pusterla N, Wilson WD, Spensley MS, et al: Diagnostic evaluation of real-time PCR in the detection of Rhodococcus equi in faeces and nasopharyngeal swabs from foals with pneumonia. Vet Rec 161:272, 2007. PUBMED Abstract
  265. Prescott JF, Coshan-Gauthier R, Barksdale L: Antibody to equi factor(s) in the diagnosis of Corynebacterium equi pneumonia of foals. Can J Comp Med 48:370, 1984. PUBMED Abstract
  266. Skalka B, Svastova A: Two techniques for detection of antibodies against Corynebacterium (Rhodococcus) equi in horse sera. Vet Microbiol 10:293, 1985. PUBMED Abstract
  267. Takai S, Kawazu S, Tsubaki S: Enzyme-linked immunosorbent assay for diagnosis of Corynebacterium (Rhodococcus) equi infection in foals. Am J Vet Res 46:2166, 1985. PUBMED Abstract
  268. Skalka B: Dynamics of equi-factor antibodies in sera of foals kept on farms with differing histories of Rhodococcus equi pneumonia. Vet Microbiol 14:269, 1987. PUBMED Abstract
  269. Takai S, Kawazu S, Tsubaki S: Humoral immune response of foals to experimental infection with Rhodococcus equi. Vet Microbiol 14:321, 1987. PUBMED Abstract
  270. Takai S, Kazama N, Tsubaki S: Radial immunodiffusion enzyme assay for detection of antibody to Rhodococcus equi in horse sera. Nippon Juigaku Zasshi 52:653, 1990. PUBMED Abstract
  271. Prescott JF, Fernandez AS, Nicholson VM, et al: Use of a virulence-associated protein based enzyme-linked immunosorbent assay for Rhodococcus equi serology in horses. Equine Vet J 28:339, 1996. PUBMED Abstract
  272. Higuchi T, Hashikura S, Gojo C, et al: Clinical evaluation of the serodiagnostic value of enzyme-linked immunosorbent assay for Rhodococcus equi infection in foals. Equine Vet J 29:274, 1997. PUBMED Abstract
  273. Higuchi T, Taharaguchi S, Hashikura S, et al: Physical and serologic examinations of foals at 30 and 45 days of age for early diagnosis of Rhodococcus equi infection on endemically infected farms. J Am Vet Med Assoc 212:976, 1998. PUBMED Abstract
  274. Cuteri V, Takai S, Moscati L, et al: A serological survey of Rhodococcus equi infection in foals in central Italy: comparison of two antigens using an ELISA test. Comp Immunol Microbiol Infect Dis 26:17, 2003. PUBMED Abstract
  275. Phumoonna T, Barton MD, Heuzenroeder MW: Recognition of a B-cell epitope of the VapA protein of Rhodococcus equi in newborn and experimentally infected foals. J Vet Med B Infect Dis Vet Public Health 52:291, 2005. PUBMED Abstract
  276. Martens RJ, Cohen ND, Chaffin MK, et al: Evaluation of 5 serologic assays to detect Rhodococcus equi pneumonia of foals. J Am Vet Med Assoc 221:825, 2002. PUBMED Abstract
  277. Phumoonna T, Muscatello G, Chicken C, et al: Clinical evaluation of a peptide-ELISA based upon N-terminal B-cell epitope of the VapA protein for diagnosis of Rhodococcus equi pneumonia in foals. J Vet Med B Infect Dis Vet Public Health 53:126, 2006. PUBMED Abstract
  278. Witkowski L, Kaba J, Rzewuska M, et al: Development of ELISA test for determination of the level of antibodies against Rhodococcus equi in equine serum and colostrum. Vet Immunol Immunopathol epub Jul 24, 2012. PUBMED Abstract
  279. Leclere M, Magdesian KG, Kass PH, et al: Comparison of the clinical, microbiological, radiological and haematological features of foals with pneumonia caused by Rhodococcus equi and other bacteria. Vet J 187:109, 2011. PUBMED Abstract
  280. Hulten C, Demmers S: Serum amyloid A (SAA) as an aid in the management of infectious disease in the foal: comparison with total leucocyte count, neutrophil count and fibrinogen. Equine Vet J 34:693, 2002. PUBMED Abstract
  281. Cohen ND, Chaffin MK, Vandenplas ML, et al: Study of serum amyloid A concentrations as a means of achieving early diagnosis of Rhodococcus equi pneumonia. Equine Vet J 37:212, 2005. PUBMED Abstract
  282. Smith BP, Robinson RC: Studies of an outbreak of Corynebacterium equi pneumonia in foals. Equine Vet J 13:223, 1981. PUBMED Abstract
  283. Ramirez S, Lester GD, Roberts GR: Diagnostic contribution of thoracic ultrasonography in 17 foals with Rhodococcus equi pneumonia. Vet Radiol Ultrasound 45:172, 2004. PUBMED Abstract
  284. Slovis NM, McCracken JL, Mundy G: How to use thoracic ultrasound to screen foals for Rhodococcus equi at affected farms. Proc Am Assoc Equine Pract 51:274, 2005.
  285. Reuss SM, Chaffin MK, Schmitz DG, et al: Sonographic characteristics of intraabdominal abscessation and lymphadenopathy attributable to Rhodococcus equi infections in foals. Vet Radiol Ultrasound 52:462, 2011. PUBMED Abstract
  286. Marchiori E, Muller NL, de Mendonca RG, et al: Rhodococcus equi pneumonia in AIDS: high-resolution CT findings in five patients. Br J Radiol 78:783, 2005. PUBMED Abstract
  287. Dungworth DL: The respiratory system. In Jubb KV, Kennedy PC, Palmer N, editors: Pathology of domestic animals, ed 4, vol 2, San Diego, 1993, Academic Press, pp 652–655.
  288. Mendoza FJ, Perez-Ecija RA, Estepa JC: Thoracic emphysematous lymphadenitis in a foal. J Comp Pathol 145:77, 2011. PUBMED Abstract
  289. Ishino S, Kumagai K, Kuniyoshi S, et al: Immunohistochemical observations on pneumonic lesions caused by Rhodococcus equi in foals. J Vet Med Sci 54:509, 1992. PUBMED Abstract
  290. Madarame H, Takai S, Morisawa N, et al: Immunohistochemical detection of virulence-associated antigens of Rhodococcus equi in pulmonary lesions of foals. Vet Pathol 33:341, 1996. PUBMED Abstract
  291. Mariotti F, Cuteri V, Takai S, et al: Immunohistochemical detection of virulence-associated Rhodococcus equi antigens in pulmonary and intestinal lesions in horses. J Comp Pathol 123:186, 2000. PUBMED Abstract
  292. Szerdi L, Makrai L, Denes B: Rapid immunohistochemical detection of Rhodococcus equi in impression smears from affected foals on postmortem examination. J Vet Med B Infect Dis Vet Public Health 48:751, 2001.
  293. Nordmann P, Ronco E: In-vitro antimicrobial susceptibility of Rhodococcus equi. J Antimicrob Chemother 29:383, 1992. PUBMED Abstract
  294. Jacks SS, Giguere S, Nguyen A: In vitro susceptibilities of Rhodococcus equi and other common equine pathogens to azithromycin, clarithromycin, and 20 other antimicrobials. Antimicrob Agents Chemother 47:1742, 2003. PUBMED Abstract
  295. Hillidge CJ: Review of Corynebacterium (Rhodococcus) equi lung abscesses in foals: pathogenesis, diagnosis and treatment. Vet Rec 119:261, 1986. PUBMED Abstract
  296. Ainsworth DM, Eicker SW, Yeager AE, et al: Associations between physical examination, laboratory, and radiographic findings and outcome and subsequent racing performance of foals with Rhodococcus equi infection: 115 cases (1984-1992). J Am Vet Med Assoc 213:510, 1998. PUBMED Abstract
  297. Lakritz J, Wilson WD, Marsh AE, et al: Pharmacokinetics of erythromycin estolate and erythromycin phosphate after intragastric administration to healthy foals. Am J Vet Res 61:914, 2000. PUBMED Abstract
  298. Prescott JF, Nicholson VM: The effects of combinations of selected antibiotics on the growth of Corynebacterium equi. J Vet Pharmacol Ther 7:61, 1984. PUBMED Abstract
  299. Giguere S, Lee EA, Guldbech KM, Berghaus LJ: In vitro synergy, pharmacodynamics, and postantibiotic effect of 11 antimicrobial agents against Rhodococcus equi. Vet Microbiol 160:207, 2012. PUBMED Abstract
  300. Peters J, Block W, Oswald S, et al: Oral absorption of clarithromycin is nearly abolished by chronic comedication of rifampicin in foals. Drug Metab Dispos 39:1643, 2011. PUBMED Abstract
  301. Venner M, Peters J, Hohensteiger N, et al: Concentration of the macrolide antibiotic tularthromycin in bronchoalveolar cells is influenced by comedication of rifampicin in foals. Naunyn Schmiedebergs Arch Pharmacol 381:161, 2010. PUBMED Abstract
  302. Jacks S, Giguere S, Gronwall RR, et al: Pharmacokinetics of azithromycin and concentration in body fluids and bronchoalveolar cells in foals. Am J Vet Res 62:1870, 2001. PUBMED Abstract
  303. Davis JL, Gardner SY, Jones SL, et al: Pharmacokinetics of azithromycin in foals after I.V. and oral dose and disposition into phagocytes. J Vet Pharmacol Ther 25:99, 2002. PUBMED Abstract
  304. Jacks S, Giguere S, Gronwall RR, et al: Disposition of oral clarithromycin in foals. J Vet Pharmacol Ther 25:359, 2002. PUBMED Abstract
  305. Castro LA, Brown MP, Gronwall R, et al: Pharmacokinetics of rifampin given as a single oral dose in foals. Am J Vet Res 47:2584, 1986. PUBMED Abstract
  306. Lakritz J, Wilson WD, Marsh AE, et al: Effects of prior feeding on pharmacokinetics and estimated bioavailability after oral administration of a single dose of microencapsulated erythromycin base in healthy foals. Am J Vet Res 61:1011, 2000. PUBMED Abstract
  307. Suarez-Mier G, Giguere S, Less EA: Pulmonary disposition of erythromycin, azithromycin, and clarithromycin in foals. J Vet Pharmacol Ther 30:109, 2007. PUBMED Abstract
  308. Drusano GL: Infection site concentrations: their therapeutic importance and the macrolide and macrolide-like class of antibiotics. Pharmacotherapy 25:1505, 2005. PUBMED Abstract
  309. Womble A, Giguere S, Murthy YV, et al: Pulmonary disposition of tilmicosin in foals and in vitro activity against Rhodococcus equi and other common equine bacterial pathogens. J Vet Pharmacol Ther 29:561, 2006. PUBMED Abstract
  310. Horohov DW, Loynachan AT, Page AE, et al: The use of streptolysin O (SLO) as an adjunct therapy for Rhodococcus equi pneumonia in foals. Vet Microbiol 154:156, 2011. PUBMED Abstract
  311. Prescott JF, Sweeney CR: Treatment of Corynebacterium equi pneumonia of foals: a review. J Am Vet Med Assoc 187:725, 1985. PUBMED Abstract
  312. Venner M, Rodiger A, Laemmer M, et al: Failure of antimicrobial therapy to accelerate spontaneous healing of subclinical pulmonary abscesses on a farm with endemic infections caused by Rhodococcus equi. Vet J 129:293, 2012. PUBMED Abstract
  313. Stratton-Phelps M, Wilson WD, Gardner IA: Risk of adverse effects in pneumonic foals treated with erythromycin versus other antibiotics: 143 cases (1986-1996). J Am Vet Med Assoc 217:68, 2000. PUBMED Abstract
  314. Lakritz J, Wilson WD: Erythromycin: pharmacokinetics, bioavailability, nonantimicrobial activity, and possible mechanisms associated with adverse reactions. Proc Am Assoc Equine Pract 43:83, 1997.
  315. Traub-Dargatz J, Wilson WD, Conboy HS, et al: Hyperthermia in foals treated with erythromycin alone or in combination with rifampin for respiratory disease during hot environmental conditions. Proc Am Assoc Equine Pract 42:243, 1996.
  316. Baverud V, Franklin A, Gunnarsson A, et al: Clostridium difficile associated with acute colitis in mares when their foals are treated with erythromycin and rifampicin for Rhodococcus equi pneumonia. Equine Vet J 30:482, 1998. PUBMED Abstract
  317. Gustafsson A, Baverud V, Gunnarsson A, et al The association of erythromycin ethylsuccinate with acute colitis in horses in Sweden. Equine Vet J 29:314, 1997. PUBMED Abstract
  318. Scheuch E, Spieker J, Venner M, et al: Quantitative determination of the macrolide antibiotic tulathromycin in plasma and bronchoalveolar cells of foals using tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci 850:464, 2007. PUBMED Abstract
  319. Venner M, Kerth R, Klug E: Evaluation of tulathromycin in the treatment of pulmonary abscesses in foals. Vet J 174:418, 2007. PUBMED Abstract
  320. Carlson K, Kuskie K, Chaffin K, et al: Antimicrobial activity of tulathromycin and 14 other antimicrobials against virulent Rhodococcus equi in vitro. Vet Ther 11:E1, 2010. PUBMED Abstract
  321. Berghaus LJ, Giguere S, Sturgill IL, et al: Plasma pharmacokinetics, pulmonary distribution, and in vitro activity of gamithromycin in foals. J Vet Pharmacol Ther 35:59, 2011. PUBMED Abstract
  322. Prescott JF: The susceptibility of isolates of Corynebacterium equi to antimicrobial drugs. J Vet Pharmacol Ther 4:27, 1981. PUBMED Abstract
  323. McNeil MM, Brown JM: Distribution and antimicrobial susceptibility of Rhodococcus equi from clinical specimens. Eur J Epidemiol 8:437, 1992. PUBMED Abstract
  324. Takai S, Takeda K, Nakano Y, et al: Emergence of rifampin-resistant Rhodococcus equi in an infected foal. J Clin Microbiol 35:1904, 1997. PUBMED Abstract
  325. Makrai L, Fodor L, Csivincsik A, et al: Characterisation of Rhodococcus equi strains isolated from foals and from immunocompromised human patients. Acta Vet Hung 48:253, 2000. PUBMED Abstract
  326. Fines M, Pronost S, Maillard K, et al: Characterization of mutations in the rhoB gene associated with rifampin resistance in Rhodococcus equi isolated from foals. J Clin Microbiol 39:2784, 2001. PUBMED Abstract
  327. Asoh N, Watanabe H, Fines-Guyon, et al: Emergence of rifampin-resistant Rhodococcus equi with several types of mutations in the rhoB genes among AIDS patients in northern Thailand. J Clin Microbiol 41:2337, 2003. PUBMED Abstract
  328. Boyen F, Pasmans F, Haesebrouck F: Acquired antimicrobial resistance in equine Rhodococcus equi isolates. Vet Rec 168:101a, 2011. PUBMED Abstract
  329. Muscatello G: Rhodococcus equi pneumonia in the foal—Part 2: diagnostics, treatment and disease management. Vet J 192:27, 2012. PUBMED Abstract
  330. Giguere S, Lee E, Williams E, et al: Rhodococcus equi isolates and treatment outcome in foals infected with antimicrobial-resistant isolates of R. equi. J Am Vet Med Assoc 237:74, 2010.
  331. Prescott JF: Lincosamides, macrolides, and pleuromutilins. In Prescott JF, Baggot JD, editors: Antimicrobial therapy in veterinary medicine, ed 3, Ames, 2000, Iowa State University Press.
  332. Wilson WD: Foal pneumonia. In Robinson NE, editor: Current therapy in equine medicine, ed 3, Philadelphia, 1992, Saunders.
  333. Womble A, Giguere S, Lee EA: Pharmacokinetics of oral doxycycline and concentrations in body fluids and bronchoalveolar cells of foals. J Vet Pharmacol Ther 30:187, 2007. PUBMED Abstract
  334. Specht TE, Frederick G: Quinolone-induced arthropathy in immature Equidae. J Am Vet Med Assoc 198:516, 1991. PUBMED Abstract
  335. Davenport CLM, Boston RC, Richardson DW: Effects of enrofloxacin and magnesium deficiency on matrix metabolism in equine articular cartilage. Am J Vet Res 62:160, 2001. PUBMED Abstract
  336. Yoon JH, Brooks RL, Jr, Khan A, et al: The effect of enrofloxacin on cell proliferation and proteoglycans in horse tendon cells. Cell Biol Toxicol 20:41, 2004. PUBMED Abstract
  337. Javsicas LH, Giguere S, Womble AY: Disposition of oral telithromycin in foals and in vitro activity of the drug against macrolide-susceptible and macrolide-resistant Rhodococcus equi isolates. J Vet Pharmacol Ther 33:383, 2010. PUBMED Abstract
  338. Schlusselhuber M, Jung S, Bruhn O, et al: In vitro potential of DEFA1 and eCATH1 as alternative antimicrobial drugs in Rhodococcus treatment. Antimicrob Agents Chemother 56:1749, 2012. PUBMED Abstract
  339. Demmers S: The outcome and survival of foals with R. equi pneumonia treated with either erythromycin and rifampin or gentamicin and rifampin. In Proceedings of the Workshop on Rhodococcus equi and Equine Rhodococcal Pneumonia, 2002, p 39.
  340. Adolph S, Fuhrmann H, Schumann J: Unsaturated fatty acids promote the phagocytosis of P. aeruginosa and R. equi by RAW264.7 macrophages. Curr Microbiol epub Aug 18, 2012. PUBMED Abstract
  341. Kellmer G, Hayes ME: Regional limb perfusion with erythromycin for treatment of septic physitis and arthritis caused by Rhodococcus equi. Vet Rec 165:291, 2009. PUBMED Abstract
  342. Giguere S, Roberts GD: Association between radiographic pattern and outcome in foals with pneumonia caused by Rhodococcus equi. Vet Radiol Ultrasound 10:1740, 2012. PUBMED Abstract
  343. Ainsworth DM, Beck KA, Boatwright CE, et al: Lack of residual lung damage in horses in which Rhodococcus equi–induced pneumonia had been diagnosed. Am J Vet Res 54:2115, 1993. PUBMED Abstract
  344. Funkquist P, Demmers S, Hedenstierna G, et al: Gas exchange during intense exercise in Standardbreds with earlier Rhodococcus pneumonia. Equine Vet J Suppl 34:434, 2002. PUBMED Abstract
  345. Christley RM, Hodgson DR: Rhodococcus equi pneumonia in foals and the effect on subsequent race performance. Aust Equine Vet 12:76, 1994.
  346. Bernard B, Dugan J, Pierce S, et al: The influence of foal pneumonia on future racing performance. Proc Am Assoc Equine Pract 37:17, 1991.
  347. Giguere S, Prescott JF: Strategies for the control of Rhodococcus equi infections on enzootic farms. Proc Am Assoc Equine Pract 43:65, 1997.
  348. Muscatello G, Gilkerson JR, Browning GF: Detection of virulent Rhodococcus equi in exhaled air samples form naturally infected foals. J Clin Microbiol 47:734, 2009.
  349. Prescott JF, Machang'u R, Kwiecien J, et al: Prevention of mortality due to Rhodococcus equi pneumonia on an endemically affected farm. Can Vet J 30:871, 1989. PUBMED Abstract
  350. Giguere S, Hernandex J, Gaskin, et al: Performance of five serological assays for diagnosis of Rhodococcus pneumonia in foals. Clin Diagn Lab Immunol 10:241, 2003. PUBMED Abstract
  351. Chicken C, Muscatello G, Freestone J, et al: Air sampling in the breathing zone of neonatal foals for prediction of subclinical Rhodococcus equi infection. Equine Vet J 44:203, 2012. PUBMED Abstract
  352. Chaffin MK, Cohen ND, Martens RJ: Chemoprophylactic effects of azithromycin against Rhodococcus equi-induced pneumonia among foals at equine breeding farms with endemic infections. J Am Vet Med Assoc 232:1035, 2008. PUBMED Abstract
  353. Venner M, Reinhold B, Beyerbach M, et al: Efficacy of azithromycin in preventing pulmonary abscesses in foals. Vet J 179:301, 2009. PUBMED Abstract
  354. Harrington JR, Martens RJ, Cohen ND, Bernstein LR: Antimicrobial activity of gallium against virulent Rhodococcus equi in vitro and in vivo. J Vet Pharmacol Ther 29:121, 2006. PUBMED Abstract
  355. Coleman M, Kuskie K, Liu M, et al: In vitro antimicrobial activity of gallium maltolate against virulent Rhodococcus equi. Vet Microbiol 146:175, 2010. PUBMED Abstract
  356. Arnold C, Chaffin MK, Cohen N, et al: Pharmacokinetics of gallium maltolate after intragastric administration in adult horses. Am J Vet Res 71:1371, 2010. PUBMED Abstract
  357. Chaffin MK, Fajt V, Martens RI, et al: Pharmacokinetics of an orally administered methycellulose formulation of gallium maltolate in neonatal foals. J Vet Pharmacol Ther 33:376, 2010. PUBMED Abstract
  358. Martens RJ, Cohen ND, Fajt VR, et al: Gallium maltolate: safety in neonatal foals following multiple enteral administrations. J Vet Pharmacol Ther 33:208, 2010. PUBMED Abstract
  359. Martens RJ, Mealey K, Cohen ND, et al: Pharmacokinetics of gallium maltolate after intragastric administration in neonatal foals. Am J Vet Res 68:1041, 2007. PUBMED Abstract
  360. Pollina GF, Zagotta G, Maritan P, et al: Pharmacokinetics of gallium nitrate after oral administration in adult horses—pilot study. J Vet Pharmacol Ther epub Sept 14:1365, 2011. PUBMED Abstract
  361. Buchanan BR, Cohen ND, Kuskie K, Pusterla N: Effect of oral gallium nitrate on the fecal shedding of virulent Rhodococcus equi. AAEP Proc 57:326, 2011.
  362. Bordin AI, Liu M, Nerren JR, et al: Neutrophil function of neonatal foals is enhanced in vitro by CpG oligodeoxynucleotide stimulation. Vet Immunol Immunopathol 145:290, 2012. PUBMED Abstract
  363. Sturgill TL, Strong D, Rashid C, et al: Effect of Propionibacterium acnes-containing immunostimulant on interferon-gamma (IFNγ) production in the neonatal foal. Vet Immunol Immunopathol 141:124, 2011. PUBMED Abstract
  364. Ryan C, Giguere S, Fultz L, et al: Effects of two commercially available immunostimulants on leukocyte function of foals following ex vivo exposure to Rhodococcus equi. Vet Immunol Immunopathol 138:198, 2010. PUBMED Abstract
  365. Siegrist CA, Barrios C, Martinez X, et al: Influence of maternal antibodies on vaccine responses: inhibition of antibody but not T cell responses allows successful early prime-boost strategies in mice. Eur J Immunol 28:4138, 1998. PUBMED Abstract
  366. Rowe J, Poolman JT, Macaubas C, et al: Enhancement of vaccine-specific cellular immunity in infants by passively acquired maternal antibody. Vaccine 22:3986, 2004. PUBMED Abstract
  367. Takai S, Kobayashi C, Murakami K, et al: Live virulent Rhodococcus equi, rather than killed or avirulent, elicits protective immunity to R. equi infection in mice. FEMS Immunol Med Microbiol 24:1, 1999. PUBMED Abstract
  368. Prescott JF, Markham RJ, Johnson JA: Cellular and humoral immune response of foals to vaccination with Corynebacterium equi. Can J Comp Med 43:356, 1979. PUBMED Abstract
  369. Machang'u RS, Prescott JF: Role of antibody to extracellular proteins of Rhodococcus equi in protection against R. equi pneumonia in foals. Vet Microbiol 26:323, 1991. PUBMED Abstract
  370. Becu T, Polledo G, Gaskin JM: Immunoprophylaxis of Rhodococcus equi pneumonia in foals. Vet Microbiol 56:193, 1997. PUBMED Abstract
  371. Varga J, Fodor L, Rusvai M, et al: Prevention of Rhodococcus equi pneumonia of foals using two different inactivated vaccines. Vet Microbiol 56:205, 1997. PUBMED Abstract
  372. Prescott JF, Patterson MC, Nicholson VM: Assessment of the immunogenic potential of Rhodococcus equi virulence associated protein (VapA) in mice. Vet Microbiol 56:213, 1997. PUBMED Abstract
  373. Taouji S, Nomura I, Giguere S, et al: Immunogenicity of synthetic peptides representing linear B-cell epitopes of VapA epitopes of VapA of Rhodococcus equi. Vaccine 22:1114, 2004. PUBMED Abstract
  374. Vanniasinkam T, Barton MD, Heuzenroeder MW: Immune response to vaccines based upon the VapA protein of the horse pathogen, Rhodococcus equi, in a murine model. Int J Med Microbiol 294:437, 2005. PUBMED Abstract
  375. Phumoonna T, Barton MD, Vanniasinkam T, et al: Chimeric vapA/groEL2 DNA vaccines enhance clearance of Rhodococcus equi in aerosol challenged C3H/He mice. Vaccine 26:2457, 2008. PUBMED Abstract
  376. Whitehead AE, Parreira VR, Hewson J, et al: Development of a live, attenuated, potential vaccine strain of R. equi expressing vapA and the virR operon, and virulence assessment in the mouse. Vet Immunol Immunopathol 145:479,2012. PUBMED Abstract
  377. Chirino-Trejo JM, Prescott JF, Yager JA: Protection of foals against experimental Rhodococcus equi pneumonia by oral immunization. Can J Vet Res 51:444, 1987. PUBMED Abstract
  378. Hooper-McGrevy KE, Wilkie BN, Prescott JF: Virulence-associated protein-specific immunoglobulin G-isotype expression in young foals protected against Rhodococcus equi pneumonia by oral immunization with virulent R. equi. Vaccine 23:5760, 2005. PUBMED Abstract
  379. Hondalus MK: Unmasking the pathogenesis of R. equi and quest for a vaccine, Proc ACVIM, 2001, p 176.
  380. Lopez AM, Hines MT, Palmer GH, et al: Analysis of anamnestic immune responses in adult horses and priming in neonates induced by a DNA vaccine expressing the vapA gene of Rhodococcus equi. Vaccine 21:3815, 2003. PUBMED Abstract
  381. Ashour J, Hondalus MK: Phenotypic mutants of the intracellular actinomycete Rhodococcus equi created by in vivo Himar1 transposon mutagenesis. J Bacteriol 185:2644, 2003. PUBMED Abstract
  382. Haghighi HR, Prescott JF: Assessment in mice of vapA-DNA vaccination against Rhodococcus equi infection. Vet Immunol Immunopathol 104:215, 2005. PUBMED Abstract
  383. Cauchard S, Bermudez-Humaran LG, Blugeon S, et al: Mucosal co-immunization of mice with recombinant lactococci secreting VapA antigen and leptin elicits a protective immune response against Rhodococcus equi infection. Vaccine 30:95, 2011. PUBMED Abstract
  384. Oliveira AF, Ruas LP, Cardoso SA, et al: Vaccination of mice with salmonella expressing VapA: mucosal and systemic Th1 responses provide protection against Rhodococcus equi infection. PLoS One 13:e8644, 2010. PUBMED Abstract
  385. Lopez AM, Townsend HG, Allen AL, et al: Safety and immunogenicity of a live-attentuated auxotrophic candidate vaccine against the intracellular pathogen Rhodococcus equi. Vaccine 26:998, 2008. PUBMED Abstract
  386. Oliveira AF, Ferraz LC, Brocchi M, et al: Oral administration of a live attenuated Salmonella vaccine strain expressing the VapA protein induces protection against infection by Rhodococcus equi. Microbes Infect 9:382, 2007. PUBMED Abstract
  387. van der Geize R, Grommen AW, Hessels GI, et al: The steroid catabolic pathway of the intracellular pathogen Rhodococcus equi is important for pathogenesis and a target for vaccine development. PloS Pathog 7:e1002181, 2011. PUBMED Abstract
  388. Pei Y, Nicholson V, Woods K, Prescott JF: Immunization by intrabronchial administration to 1-week old foals of an unmarked double gene disruption strain of Rhodococcus equi strain 103+. Vet Microbiol 125:100, 2007. PUBMED Abstract
  389. Kedlaya I, Ing MB, Wong SS: Rhodococcus equi infections in immunocompetent hosts: case report and review. Clin Infect Dis 32:39, 2001. PUBMED Abstract
  390. Yamshchikov AV, Schuetz A, Lyon GM: Rhodococcus equi infection. Lancet Infect Dis 10:350, 2010. PUBMED Abstract
  391. Guyssens V, Vandekerckhove L, Colle I, et al: Invasive infection with Rhodococcus equi—two case reports and review of literature. Acta Clin Belg 65:271, 2010. PUBMED Abstract
  392. Doig C, Gill MH, Church DL: Rhodococcus equi: an easily missed opportunistic pathogen. Scand J Infect Dis 23:1, 1991. PUBMED Abstract
  393. Rasmussen TT, Kirkeby LP, Poulsen K, et al: Resident aerobic microbiota of the adult human nasal cavity. APMIS 108:663, 2000. PUBMED Abstract